NIPT reference library

Academic studies and papers associated with NIPD and NIPT

Cost effectivness


Conner P, Gustafsson S, Kublickas M. First trimester contingent testing with either nuchal translucency or cell-free DNA. Cost efficiency and the role of ultrasound dating. Acta Obstetricia et Gynecologica Scandinavica. 2015;94(4):368-75.

Teitelbaum L, Metcalfe A, Clarke G, Parboosingh JS, Wilson RD, Johnson JM. Costs and benefits of non-invasive fetal RhD determination. Ultrasound in Obstetrics and Gynecology. 2015;45(1):84-8.


Neyt M, Hulstaert F, Gyselaers W. Introducing the non-invasive prenatal test for trisomy 21 in Belgium: a cost-consequences analysis. BMJ Open. 2014;4(11):e005922.

Beulen L, Grutters JP, Faas BH, Feenstra I, van Vugt JM, Bekker MN. The consequences of implementing non-invasive prenatal testing in Dutch national health care: a cost-effectiveness analysis. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2014;182c:53-61.

Evans MI, Sonek JD, Hallahan TW, Krantz DA. Cell-Free Fetal DNA Screening in the United States: A Cost Analysis of Screening Strategies. Ultrasound in Obstetrics and Gynecology. 2014. [Epub ahead of print]

Okun N, Teitelbaum M, Huang T, Dewa CS, Hoch JS. The price of performance: a cost and performance analysis of the implementation of cell-free fetal DNA testing for Down syndrome in Ontario, Canada. Prenat Diagn. 2014 34(4):350-6.

Morris S, Karlsen S, Chung N, Hill M, Chitty LS. Model-Based Analysis of Costs and Outcomes of Non-Invasive Prenatal Testing for Down’s Syndrome Using Cell Free Fetal DNA in the UK National Health Service. PLoS One. 2014 9(4):e93559.


Ohno M, Caughey A. The role of noninvasive prenatal testing as a diagnostic versus a screening tool – a cost-effectiveness analysis. Prenat Diagn. 2013 Jul;33(7):630-5.

Cuckle H, Benn P, Pergament E. Maternal cfDNA screening for Down syndrome – a cost sensitivity analysis. Prenat Diagn. 2013 33(7):636-42.


Hill MK, Sally Taffinder S, Chitty LS, Morris S: Incremental cost of non-invasive prenatal diagnosis versus invasive prenatal diagnosis of fetal sex in England. Prenat Diagn 2011; 31: 267-73.